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Beilstein J. Org. Chem. 2020, 16, 509–514, doi:10.3762/bjoc.16.46
Graphical Abstract
Figure 1: The dual role of DBU in the amidation of 7-CMP.
Scheme 1: DBU-promoted amidation of 7-CMP (1).
Figure 2: Role of a β-hydroxy group in aiding the amidation reaction.
Figure 3: Pseudo-first order kinetics for representative amines.